Zinc dopamine reddit like not nearly enough. A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. Symptoms of Zinc deficiency could be (not exclusive list and these symptoms could be caused other factors as well): The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. But vitamin c and tyrosine. Zinc and iron blood levels of at least 100. Here are some reasons why zinc could work for social anxiety or hesitation: Zinc deficiency and anxiety: Low levels of zinc have been linked to symptoms of depression and anxiety. Zinc promotes gaba production (aswell as glycine) this competes with dopamine and can lower dopamine causing irritability and anger if you are already low! You can try to offset this by taking tyrosine which increases dopamine! It's a tricky & complicated balance. Using co-forms of zinc that have other uses in the body like zinc sulfate, (which you are) and zinc glycinate instead of zinc picolinate or zinc gluconate is superior as picolinate & gluconate are worthless binding agents once cleaved from the zinc in digestion. Take 1g a day. Creatine: Study Link Yeah but that dopamine isn't from the drug it's from the drug interacting with your body to trigger dopamine's creation. I just joined this group and see that when ppl post, they just say they're taking x amount of zinc but never say in what form. I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. There are two 'types' of dopamine: tonic and pulsatile. Probably not. Nov 13, 2021 · The link between iron and zinc supplementation and the observed decrease in ADHD symptoms in the controlled clinical trials selected for this systematic review also makes sense with regard to the role of zinc and iron as dopamine reuptake inhibitors, which was precisely the core target of the stimulant medications used in the combined treatment Zinc increase dopamine and testosterone and both can increase arousal even in non deficient people . basically disfunctional until 1-2 pm. I don’t know exactly how it does it even though it does increase dopamine in the short term, but the side effect is is common enough it’s become a trend among teens to use it as a way to become apathetic. Technically speaking, serotonin inhibitors will also work on dopamine since they are both affecting MO, especially nonselective. Jan 16, 2025 · Zinc to Copper ratio of 15/1 seem to deplete Copper. Evidence of this speculation is found with the shared symptoms that result from individual nutrients that have similar effects on specific neurotransmitters (ex. Get the Reddit app Scan this QR code to download the app now Zinc can cause a one-time spike in dopamine levels if you've been mildly or moderately deficient. Dopaminergic Neurotransmission. Zinc increases dopamine. “In noradrenergic neurons, Cu is needed for activity of dopamine-β-hydroxylase (DBH), which converts dopamine to norepinephrine and is required for catecholamine balance” “Cu is required for myelination of neurons [ 13 ], and it influences synaptic transmission by modulating functions of GABA and NMDA receptors, as well as voltage-gated The 4 supplements are: Zinc, Creatine, NAC and Fish Oil Zinc: Study Link. Your symptoms are possibly what people refer to as "overmethylation". I suggest the glycinate form. Dopamine is considered to be associated with tons of other effects that have to do with the bigger result of pleasure/euphoria and also more random ones, such as anticipation, repeating behavior, muscle contraction, and more; essentially it plays a big role in the cycle/process of the concept of "reward". Zinc antagonizes copper - you might be feeling the effects of the copper being stirred up and overstimulating the nervous system. L-Tyrosine is my goto/must have for keeping my Dopamine reward system working optimally. This is based on a group that supplements 5mg+ per day. I read that max zinc per day is 30-40mg Zinc binds to the dopamine transporter and slows it down, allowing dopamine to remain active in the synapse for a longer period of time before being pulled back into the cell to be recycled. The original formula consists of mag aspartate, and aspartate is excitatory. Assuming we're facing weeks, maybe even months without proper access to medication, I guess it's time to dust off a few of those old coping strategies. My parents didn't place much stock on it, who needs zinc right, certainly not a 6 year old! I've honestly felt better on Zinc and Iron supplements, my severe PMS almost vanishes, my mood improves, I don't suffer frequent burnouts, I'm more focused and I'm not fatigued. Dopamine reuptake inhibitors, on the other hand, are unable to cause euphoria, even if they are injected in very high doses. I cut one 25mg pill to half and take a half every day, that’s all you need. I normally don't drink coffee. Novos labs longevity protocol says to take them separately because they compete for similar pathways. B6 as pyridoxine HCL is garbage, and P5P can also be stimulating. It's actually not necessarily paradoxical - Zinc potentiates dopamine release by Amphetamine (through DAT allosteric modulation), but at the same time, it might also decrease dopamine production (through inhibition of iron binding to TH). A DRI the mechanism of action at the dopamine transporter (DAT) for dopamine releasers/substrates is entropy-driven (i. Dopamine addiction is not a thing. Animal studies show that higher zinc levels can decrease dopamine levels by inhibiting iron. , 2015), but a role for zinc homeostasis with respect to clinical depression and psychosis is not well appreciated by psychiatrists. and dopamine. liver, kidneys, brain), then that be affected by taking zinc. Anyways, stick with those precursors and then stay off of tv and your phone. Does the zinc you used contain vitamin B6 also, by the way? Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. There are no studies that point to an increase in dopamine or noradrenaline due to concurrent zinc supplementation. This makes the pulses of dopamine small in comparison. Still, both are significantly different than what is in the brand you have been taking. Taking a single shot of sulbutiamine increases dopamine release. They do this in part by reversing the DAT, so that rather than shuttling dopamine back into the neuron, it transports dopamine out of the neuron. 😊 We discuss the wonderful ways the autistic brain functions! Zinc is a surprisingly effective supplement as well, and actually is a subtle dopamine re-uptake inhibitor. Its general actions are well reviewed, as briefly described in this paper and several excellent reviews (Marger et al. I’ve done this and it’s worked great but… I was wondering what are some other ways you can increase your dopamine naturally ? I’m really struggling to focus these days even though I’m on Fatigue can be caused through multiple pathways: 1- Lower norepinephrine due to low Dopamine Beta Hydroxylase activity (a Copper enzime that tranaforms dopamine into norepinephrine). So it looks like the Tory government and our crumbling health service have comprehensively hung us out to dry. According to this study, high dose Zinc supplementation (60ppm in drinking water, equal to 60mg per day in humans) does not change brain zinc at all: Mice fed high dietary zinc showed significantly increased zinc level in serum and hemocytes, but the total brain zinc level was not changed. The fact that you are vegan won t make you automatically deficient in zinc if you eat legumes and nuts. Zinc is also important to thyroid. But I could not find anything suggesting there is such a variant. Furthermore, zinc supplementation is well known to boost testosterone. Zinc will regulate copper levels. Magnesium Glycinate - 400-600mg / day split over day. Last time this happened only time fixed it. Magnesium is helpful. The question is asking how do people get high when the body doesn't have the resources to provide the dopamine creation the drug triggers. A daily intake of 60 mg of zinc for 10 weeks (10 mg from the diet and 50 mg from a zinc supplement) was associated with a decrease in copper status. I feel incredible energy, anxiety gone, super social, sex drive sky high. Why would this be beneficial if schizophrenia correlated with high dopamine in which zinc supplementation would only increase further? Nov 3, 2021 · Background Dopamine (DA) is a neurotransmitter that plays roles in movement, cognition, attention, and reward responses, and deficient DA signaling is associated with the progression of a number of neurological diseases, such as Parkinson’s disease. Copper supplementation is necessary to prevent deficiency when supplementing high dose zinc, however at 30mg zinc per day you should be fine. Whereas the two studies in which increased immobility time in the FST following 2 weeks of the diet utilized the zinc-deficient diet containing 0. According to a 2021 study, zinc does The optimal ratio is said to be anywhere between 8:1 Zinc:Copper to 15:1 Zinc:Copper; there is no universal agreement on the optimal ratio. So, a 50mg tab of zinc gluconate would be roughly 7mg of elemental zinc. Are you sure that's the problem? If you absolutely are sure, then check your zinc/copper levels. Dopamine-β-Hydroxylase has 2 cofactors copper and Vit C. Dopa, a precursor of dopamine is oxidatively produced from tyrosine by the copper enzyme tyrosinase. Also there’s zinc lozenges and cold medicine! Edit: missing word I've recent been taking Maca and the effects have been huge for me. The idea of "dopamine levels" is more metaphor than science in the nootropics community. In addition, zinc supports one of the fundamental ingredients for mental health — dopamine. When you get your dopamine, research increasing dopamine receptor density. Each form has a different conversion to elemental zinc. Amen low dopamine is related to attention problems. AlphaGPC is the one for Acetylcholine, but it does have an unfortunate side-effect because if you take it every day, it feeds some “bad” bacteria in your gut biome, that convert Choline into mildly toxic TMAO. If you maintain this for several weeks your receptors will increase their sensitivity to return you to baseline. Per Dr. α-Amidating monooxygenase (α-AE), also called peptidylglycine α-AE, uses copper and ascorbate to remove two car- bons from a C-terminal glycine of peptides, thus generating an amide. In general, it was like drinking too much caffeine. Different dopamine receptors can have opposite effects depending on their location in the synapse (pre- or post- synaptic) or in different brain regions. hydrophobic), whereas for dopamine re-uptake inhibitors it is enthalpy-driven (i. There’s 2 camps that vary in some of the subtleties but they’re both pro copper, iodine, b vitamins, real vit C and then it seems to vary on zinc & other minerals supplements depending on your body make up and general health. If both occur at the same time, though, Amphetamine could deplete dopamine stores faster. Maybe your getting a bump in some of the more stimulating ones. to get 20 mg of zinc can take upwards of 200 mgs of zinc supplements and if your doing that then throw in some copper Jun 29, 2017 · Introduction. Your common SSRI that is probably the most effective is St. Dopamine is a neurotransmitter involved in the motivation and reward pathways. Continuous use reduce average dopamine levels. I normally have severe social anxiety and symptoms of CPTSD. The RDA for Zinc is 11mg daily for adults, and the RDA for Zinc is 0. conformational change). Although zinc is widely prometed as a life changer mineral, it's still a heavy metal and when taken in excess; you won't pee out the unnecessary amount like the case in Vitamin C. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. Your symptoms sound like adrenal dysfunction to me. I think people should search for and read the studies instead of believing the bro- nonsense that they read on reddit. You end up in higher dopamine state after DBM inhbition. Zinc is also said to be stimulating as it is possibly a weak dopamine reuptake inhibitor. The results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs). I use zinc, b6, and tyrosine for anti prolactin. If you have hidden copper toxicity - excess copper stored in the tissues (i. Herein, we report a host-cell-specific direction of the Zn(2+ … Dec 27, 2024 · I got 160mg of zinc citrate supps of which 50mg is elemental zinc but that seems too high. The enzyme that converts L-DOPA into active dopamine, L-dopa decarboxylase, is a pyridoxine-5'-phosphate (PLP) dependent enzyme and due to the actions of pyridoxine infusion paralleling that of dopamine (in regards to prolactin and growth hormone) it is thought that additional pyridoxine increases the activity of this enzyme particularly in the hypothalamus. Done sleep studies and blood tests (only high creatinine and familial cholesterol). According to a 2021 study, zinc helps elevate levels of brain-derived neurotrophic factor (BDNF) in the areas of our brain that control our emotions. I have heard of selective SSRI in high dosage affecting dopamine. The link is strong enough that the degree of zinc deficency can accurately predict the severity of depression. May in my case would be worth trying aswell, one of the most basic approeches. Zinc has completely changed my life. 35% elemental zinc by wright. , 2014; Nowak, 2015; Prakash et al. High doses of zinc long-term can cause copper deficiency and vice versa. Folate upregulating production of dopamine and zinc inhibiting dopamine reuptake; the result being the same negative feeling). But I also don't know how dopamine would be low and norepinephrine would be high unless the enzyme DBH - which converts dopamine to norepi - had some variant which upregulates the conversion rate. Long-term L-Dopa supplementation has potential to downregulate Dopamine synthesis. 9mg for adults. You can find studies where taking 3 mg of zinc daily reduces the amount of dexamphetamine you have to take to get the same results by 30 %. I don’t get how people actually benefit from it. Apparently (too much) zinc can affect brain dopamine binding, you can research this by googling zinc dopamine. 10/1 seem ok for some, others do well all the way down to 1/1 ratio. Keep in mind you also get zinc from foods as well, so you are likely overdosing on zinc without even realizing. Nor does zinc do anything for ADHD if you are not deficient in the mineral. The only time to take extra zinc would be at the onset of cold/flu symptoms, and that’s only to lessen the severity/length of the cold/flu. Summary: Bromantane increases dopamine synthesis, balances excitatory and inhibitory neural networks, and increases neurotrophins by reducing neuroinflammation through epigenetic mechanisms. I'm extremely sensitive to increases in dopamine because of some weird neurological problems I have. What others do YOU know? Little educational post attempt here, let's all share our knowledge on this to help each other out. In large amounts, monoamine releasing agents tend to be neurotoxic. RDA of zinc is 11mg, no one needs that much zinc. In all honesty, it probably only makes a difference if you're a regular user. 37 mg zinc/kg and the zinc-adequate diet containing 52. Hello everyone, In the episode about dopamine,Huberman says that you can raise your base line “wavepool” of dopamine by taking a cold shower. For everyone out there, this doesn't mean now you should take a lot of zinc forever. I did seem to have an increase in mood (or I should say a reduction in negative mood), but noticed I was putting on water weight. Manganese is important to the thyroid as well. This way, simple things will give you the dopamine boost. After cessation of daily dosing, your dopamine levels will increase, but the sensitization will last for a few months. Have had that experience with both Vyvanse and Dexamphetamine Dopamine based stimulants will deplete your Sodium levels so make sure you're getting enough of your electrolytes; Sodium, Potassium etc. (Over 80%) You can find liquid zinc sulfate on Amazon for like 15-20 bucks. Perfect! Then definitely don’t take extra zinc. It seems like maybe I need it the most but just need to start off smaller because 8 mg made me feel kryptonited. BUT: When you first start taking zinc, it might make you feel like it's having the opposite effect. That is made of distilled water, ethyl alcohol, zinc sulfate and b6 p5p Highly recommend taking a methylated b-complex, (or b2 and p5p at the least) Molybdenum, Zinc Glycinate, and Selenium (2 Brazil nuts covers selenium needs) Glycine (3g a day before bed) and Vitamin C and/or PQQ, in order to cover all of the cofactors NAC needs and prevent side-effects. possible its the zinc supplement reducing supply of tyrosine. However, it wasn't until recently that scientists examined the compounds in the plant and discovered that many of them can reduce prolactin as much as dopamine itself (7). L-tyrosine or N-acetyl-l-tyrosine are better options that will effectively raise dopamine levels and are safe to supplement long-term, although work even better when cycled. This could lead to a higher conversion from Dopamine to Norepinephrine and can be counteracted by supplimenting Zinc. IT is a rate iimited dopamine precursor. Stop doing those first and your dopamine will come back and cortisol will lower. Vitex Agnus Castus, also known as Chaste berry, has long been used as a treatment for sexual disorders and insufficiency. Excess copper leads to higher epinephrine production, tanking dopamine. It keeps my ratio where it needs to be, and I've only ever struggled with zinc deficiency not copper. Slow COMT is associated with high tonic dopamine. I started taking a zinc+copper supplement and felt more energy at first, but quickly become overloaded in copper and became extremely irritable. Due to its critical functions, DA expression levels in the brain are tightly controlled, with one important and rate-limiting step in its According to this study, 30mg elemental zinc daily for 13 weeks (final five weeks used alongside D-amphetamine) was able to reduce the amount of D-amphetamine that was needed by 37% and reduced affective blunting from 21% (placebo with amphetamine) to 11%. B-vitamins generally increase methylation levels (the outlier here would be B3) and, in turn, raise monoamine levels (e. Feel amazing after pmo as opposed to depressed, with brain fog etc. Zinc gluconate has been much more effective for me. Zinc is an essential trace element required by all organisms for various biological processes. edu Theoretically same for Zinc - Copper pair Maybe you should look into electrolytes, and drink a mix of potassium + magnesium + salt + zinc. Most common is 3/1 to 5/1. ” Zinc has a multitude of functions in the body, including reducing oxidative stress, modulating neurotransmitter receptor function, and regulating gene expression. Increasing your daily zinc intake can help improve symptoms. The possible mechanism behind this effect would be the fact that picolinic acid is Dopamine beta-monooxygenase (DBM) inhibitor. Just commenting for balance. That along with too much cortisol. Not recommended. The only one that I know of is extract from Nightshade plant. Evidently Bacopa acts similarly to NAC and I felt so shitty I almost tried to find a therapist. 20 mg of zinc is very little. This is a good thing, as it prevents zinc toxicity. Dopamine releasers cause euphoria in high doses and therefore might pose a risk for people with addictive personalities. As a neurotransmitter, dopamine enables the mind and muscle to work together, increasing the benefits that occur from weightlifting. On a side note, I’ve tried zinc for many years and always had to come off because it would cause side effects. Also there are distinct metabotropic receptors that bind zinc in the brain and an immediate search pulls up a journal article that mentions it has interactions with AMPArs and 5HT1Ars + mTOR among other places. It got rid of my anhedonia, depression, anxiety and what I thought was permanent sexual dysfunction caused by SSRI treatment. Ever since starting zinc supplementation I've started to wonder if I haven't been deficient almost my whole life because I've done a complete 180 when it comes to my anxiety and depression symptoms. Remember the copper-zinc inverse relationship regarding their absorption. You need to have a baseline stimuli free of bombardment. e. That is how you start feeling those weird feelings. All this is good, but the problem is that while zinc is the signal for producing metallothioneins, these proteins bind to copper better than they do to zinc. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. Not only is dopamine important for muscle building benefits, but it can also counteract depression. I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. Tonic dopamine is the rather constant background level, whereas pulsatile are the brief spikes due to some stimulus. Successful antidepressant treatment can raise zinc levels. Increased dopamine receptor density is not necessary for the upregulatory action of Bromantane. Zinc may potentiate Cocaine by faciliating its binding to DAT. Zinc inhibits prolactin in the CNS, increases thyroid hormone activity and antagonizes NMDA receptors. iirc zinc has positive effects on dopamine signaling. Take it with your adderall for a better peak and easier comedown, or take it as the last adderall is wearing off in order to mitigate the comedown almost entirely. "The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. Obviously 30 mg is less than the 50 mg tested in the study and is also within the upper limit dose of 40 mg of zinc a day for adults outlined by The National Institutes of Health. Zyban. The bioavaliabilty of zinc supplements is very low, as little as in the teens depending on type, and the all vary. . I take plenty of both zinc and copper too. Just off hand I can recall a zinc taste acuity test double blind 300 participant's that also took zinc blood plasma lvls and found the zinc taste test to be pretty damn accurate. minerals: zinc 20 mg, copper 2 mg (10% of zinc amount to prevent copper depletion, although Cu is an oxidant), selenium 100 mcg endogenous compounds: acetyl-carnitine (ALCAR) 1000 mg, lipoic acid 600 mg, ubiquinol (CoQ10) 100 mg, beta-alanine 1600 mg been struggling with severe morning groginess and brain fog for years. It is also anecdotally reported to give people vivid dreams and a significant increase in appetite, 2 effects commonly seen in people who use dopamine agonists. Dopamine isn't a simple variable that you can raise or lower within the brain for a desired effect. g. I couldn’t get my copper levels up to “in range” so i just settled on a 15mg zinc glycinate daily Drugs like ecstasy or molly blow all your dopamine levels and take many days to replenish. true. They might be better for people with addictive personalities. Supplementing zinc has made me feel great. " Having Zinc at the same time as your meds will definitely potentiate Adderall. Mar 28, 2022 · Lower levels of zinc have been linked to symptoms of depression and anxiety. This community is focused on neuroscience research of how autism, ADHD, OCD, schizophrenia, schizoaffective etc presents in women. My sensory processing sensitivities become more manageable. These epithelial cells shed every 5-6 days, and the metallothioneins with their bound excess zinc are shed too, and excreted in feces. B vitamins on the other side 66 votes, 75 comments. Additionally, zinc is a fairly easy nutrition to obtain from food. My mother took it (because her doctor told her to) when she was dying from cirrhosis of the liver. There's an entire book out there just about this relationship and all the chaos that follows up when imbalanced. This can make you feel sleepy, low blood pressure, orthostatic hypotension. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) I took a few weeks off it and supplemented with zinc and copper and eventually felt normal. Watch his video on dopamine and the analogy of the tidal wave pool. 30mg elemental zinc appears to be slightly effective as an addition to D-amphetamine therapy. But even one dose now completely obliterates my dopamine system. So my muscles got tense and I had trouble sleeping. The study is specifically with cocaine addicted mice, and basically zinc made them do more coke than usual (presumably because it made it better, dopamine is the best part of coke). Do you mean dopaminergic drug addiction? You can't be addicted to dopamine, part of addiction involves dopamine dysfunction that usually arises from illness, environmental pollution, or most commonly, drug abuse. DBM normally converts dopamine to norepinephrine. I've seen many threads on reddit regarding this form of zinc and such reaction. Prolactin is known as the anti dopamine hormone so more dopamine offsets it's crap. I think zinc is known to boost dopamine for one which would 100% cause a rise in anxiety. I would strongly recommend trying those before trying SAM-e. Also giving blood to remove iron due to iron overload in body. Zinc plays a large role in how we react to stress and deficiency is linked to depression. 326,327 Importantly, zinc may inhibit neuronal NMDA glutamate receptors, which are dysregulated in those with depression, and raise BDNF levels, which can promote neuroplasticity TL;DR: Zinc potentiates Cocaine in mice; low-Zinc diets attenuate Cocaine's stimulant action - human Cocaine users with low Zinc levels consume more Cocaine, perhaps to cover up for a possible dopamine deficit created by a low Zinc level. If you are low in iron (and thus reduced dopamine synthesis), be sure that you aren’t taking iron or eating iron-rich foods alongside a zinc Zinc plays a big role in neurotransmitter synthesis. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. The fact that dysfunction of the dopamine transporter is involved in the pathogenesis of … A plausible explanation is that 5-10% of people of sensitive to supplements and can have strong reactions. Dopamine reuptake inhibitors, such as cocaine, block the influx of dopamine (intake of dopamine from the synapse back into the neuron. I started taking 50 mg of P5P at my doctor's recommendation in order to increase dopamine; B6 is a major cofactor for speeding up the enzyme that converts l-dopa to dopamine but also histidine to histamine. Hi, we likely have the same issue. Like zinc gluconate is 14. Copper and Zinc are Antagonists, a lot of stress and depression can deplete Zinc. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL A common long term side effect for ashwaganda is reported to be anhedonia. It is essentially a natural “dopamine reuptake inhibitor. Excess copper converts your dopamine to norepinephrine, I felt psychotic and it took a couple of days supplementing zinc alone to feel normal again. Certain pairs of things need to be kept balanced in the body, such as zinc-copper or dopamine-serotonin. The There are a number of ways zinc does this, but some of these include: •prevents your brain from becoming overexcited at NMDA receptors •helps create/regulate serotonin, GABA, dopamine •increases BDNF According to Trudy Scott, the zinc taste test can help determine if you need zinc! Google it! The symptoms of Autism include a lack of willingness to make eye contact, repeated tasks etsWhich some studies were ameliorated with glycine, arginine, zinc, and creatine ( I can't find the study at the moment)My current stack is: Lysine, acetyl L carnitine, COQ10, Zinc, selenium, vitamin C and Iron ( every two days) and probiotics For example, a Harvard article titled "Nutrition's dynamic duos" discusses the effects of high amounts of zinc causing copper deficiency so they recommend adding copper to zinc supplements. Jarrow Zinc Balance is a nice low dose of zinc and copper 15mg:1mg. I'm 21, lift weights 5x a week, eat generally well and high protein, take daily vitamin d, omega 3, zinc, magnesium. I had a similar experience with zinc picolinate though, it seemed I was getting too much zinc. Cocaine appears to lower your zinc levels, that's why supplementing seems to help. 8 mg zinc/kg [21, 68], similarly, we utilized the following diets: zinc-deficient 3 mg zinc/kg; zinc-adequate 50 mg zinc/kg , the study which did I took 40 mg of combined zinc biglycinate + zinc picolinate, and I have seen a pretty alarming decline in work motivation. Or - might be much better - make sure to eat daily 2 tomatos + 1 avocado + 1 paprika + 1 leaf of bok choy + water + salt + eat good meat / fish = and never worry about taking any supps again There’s a couple groups that are promoting copper due to deficiencies. John's Wort. Helps Produce Dopamine. D of 80. Can attest myself after several years on and off. yeah my first panel showed a slight deficiency in both zinc and copper, i started zinc and watched my copper deficiency get worse so i began taking 2mg copper bisglycinate alongside (but at different times) 30mg zinc picolinate. The dopamine transporter is regulated by zinc (Zn2+), which directly interacts with the transporter protein as a potent non-competitive blocker of substrate translocation (dopamine transport inward and outward). This is a good reminder that if you are taking zinc as a supplement, it can interact with iron absorption. Also consider also using topical DIY Zix for further non systemic topical DHT reduction. Recently I made the mistake of trying NAC and Bacopa back to back. ---nap . ZMA is not really a good product. I took 8 mg and it was way too strong for me. dopamine, serotonin), which some people seem to be unable to properly regulate. ggufu ovhozl ese zdz jfiea vehmwh rlazn rgqa gwkct tqd hfeyhulb tij zpqmat sppazo obmlaz